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Scn10atm2(cre)Jwo - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Scn10atm2(cre)Jwo
sodium channel, voltage-gated, type X, alpha; targeted mutation 2, John N Wood 		Driver: Scn10a
Type: Targeted (Recombinase)
Synonym: nav1.8-cre, NaV1.8Cre, Nav1.8Cre, Scn10atm2(cre)Jnw
Molecular description: Cre recombinase, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. Cre expression was observed beginning at embryonic day 14 in small-diameter neurons in dorsal root, trigeminal, and nodose ganglia but absent in nonneuronal and CNS tissues.
Find mice (IMSR): Mouse Strains: 3 strains available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:92442 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 123 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory