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Pgrtm2(cre)Lyd - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Pgrtm2(cre)Lyd
progesterone receptor; targeted mutation 2, John P Lydon 		Driver: Pgr
Type: Targeted (Recombinase)
Synonym: Pgrcre, PR-Cre, PRCre
Molecular description: Cre recombinase cDNA was inserted into exon 1. An untranslated region was created immediately 5' of the cDNA by mutating the ATG codon for the B isoform to prevent an in-frame fusion from the N-terminal of the cre cDNA to the remaining 120 amino acids at the N-terminal end of the endogenous gene. A loxP-flanked neo was inserted 3' of the cre insertion. RNase protection analysis demonstrated that cre transcription was restricted to progestin target tissues, including the uterus, mammary gland and oviduct/ovary.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Pgrtm2(cre)Lyd activity also observed in:
alimentary system, hemolymphoid system
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 206 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory