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Grid2tm1(cre/PGR*)Ksak - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Grid2tm1(cre/PGR*)Ksak
glutamate receptor, ionotropic, delta 2; targeted mutation 1, Kenji Sakimura 		Driver: Grid2
Type: Targeted (Inducible, Recombinase)
Inducer: mifepristone
Synonym: D2CPR, GluRdelta2CrePR, Grid2tm1(cre/PGR)Ksak
Molecular description: The targeting vector consisting of a fusion protein of Cre recombinase plus a modified ligand binding domain of the human progesterone receptor and pgk-neo-polyA cassette was inserted in the translational initiation site of the Grid2 gene in frame. Approximately 900bp nucleotides from the initiation site of the endogenous sequence were deleted. The ligand-binding domain of human progesterone receptor was modified such that it binds and can be activated by the synthetic steroid, RU486, but not by the endogenous ligand, progesterone. Upon induction of inserted cre/PGR expression with RU486, activity was noted in mature Purkinje cells of the cerebellum.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Grid2tm1(cre/PGR*)Ksak activity also observed in:
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Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory