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Tg(Tyr-cre/ERT2)1Lru - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tyr-cre/ERT2)1Lru
transgene insertion 1, Lionel Larue 		Driver: Tyr
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Tg(Tyr-cre/ERT2)1Laru, Tyr::Cre-ERT2, Tyr::CreERT2-Lar
Molecular description: This transgene expresses a tamoxifen-inducible form of cre recombinase under the control of the tyrosinase enhancer and promoter, active in melanoblasts and melanocytes. The transgene inserted on the proximal end of chromosome 7 fused to a ~3 million base pair duplication from the proximal end of chromosome 2. This insertion also caused the deletion of some chromosome 7 loci. Specifically, the insertion occurred on chromosome 7 into exon 10 of the Nlrp12 locus (3,220,560; mouse mm10), causing deletion of centromeric sequences including the entire Speer9-ps1 and Au018091 loci as well as the remaining 3' Nlrp12 sequences. The duplicated chromosome 2 sequences (now fused to the transgene on chromosome 7) include the entire Fam171a1, Nmt2, Rpp38, Olah1, Meig1, and Dclre1c loci, as well as a portion of Suv39h2 lacking exons 1-2. Therefore, animals hemizygous for the Tg(Tyr-cre/ERT2)1Lru allele carries three copies of the duplicated chromosome 2 genes, but only one functional copy of the deleted chromosome 7 genes.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tyr-cre/ERT2)1Lru activity also observed in:
embryo-other, integumental system
Images
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J:105276 Fig. 5 J:105276 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 32 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory