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Tg(Tyr-cre/ERT2)13Bos - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tyr-cre/ERT2)13Bos
transgene insertion 13, Marcus Bosenberg 		Driver: Tyr
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Tyr::CreER, Tyr::CreERT2, Tyr::CreERT2-Bos
Molecular description: This transgene consists of a 5.5 kb fragment of the Tyr promoter and a 3.6 kb fragment of the Tyr enhancer driving expression of a tamoxifen-inducible form of cre recombinase. 3 lines were generated which all showed tamoxifen-inducible Cre activity in cutaneous melanocytes. This is a representative record for all 3 lines. Line 13 contains 2 copies of the transgene inserted into chromosome 2 (chr2:129,989,606; NCBI37/mm9) 7.8 kb downstream of Snrpb and 9.6 kb downstream of Tgm6 with a 3 kb deletion at the integration site. In addition, three or more copies of the transgene were integrated on chromosome 2 resulting in ~3 kb deletion of this intergenic region between base pairs 130,160,936 and 130,163,877 [mouse mm10].
Find mice (IMSR): Mouse Strains: 12 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tyr-cre/ERT2)13Bos activity also observed in:
alimentary system, endocrine system, head, hemolymphoid system, limbs, sensory organs
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Images
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J:110143 Fig. 2 J:253583 Full Image
Fig. Tyr adult hair follicle J:253583 Full Image
Fig. Tyr adult skin J:311103 Fig. S2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 160 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory