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Tg(Col2a1-cre/ERT)KA3Smac - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Col2a1-cre/ERT)KA3Smac
transgene insertion KA3, Susan Mackem 		Driver: Col2a1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Col2CreERT, Tg(Col2a1-cre/ESR1)1Smac, Tg(Col2a1-cre/ESR1)KA3Smac
Molecular description: This transgene expresses a tamoxifen-inducible form of cre recombinase driven by the Col2a1 promoter in cartilage. The cre recombinase coding region is joined to a sequence encoding the ligand-binding domain of the human estrogen receptor with glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Col2a1-cre/ERT)KA3Smac activity also observed in:
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:111627 Fig. 1 J:111627 Fig. 5 J:111627 Fig. 6 J:111627 Fig. 7 J:184578 Full Image
Fig. Col2a1 Bone P56 J:184578 Full Image
Fig. Col2a1 Sp Column P56 J:213921 Fig. S7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 81 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory