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Slc6a3tm1(cre)Xz - Head
Recombinase Activity Detail
Allele Information
Allele:
Slc6a3tm1(cre)Xz
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Xiaoxi Zhuang 		Driver: Slc6a3
Type: Targeted (Recombinase)
Synonym: DAT-cre, Slc6a3Cre
Molecular description: A targeting vector was constructed by inserting a cassette with the cre recombinase coding sequence, a nuclear translocation signal, and a PGK-neo gene flanked by FRT sites, into the 5'-UTR of the Slc6a3 gene. After homologous recombination in ES cells, mice with cre recombinase expressed from the Slc6a3 gene were produced. Knockin mice were crossed with transgenic Flp deleter mice to remove the neo marker. A line was established where the neo was removed and the Flp transgene was absent. Cre recombinase expression is detected in the ventral tegmental area (VAT) and substantia nigra zona compacta (SNc).
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Slc6a3tm1(cre)Xz activity also observed in:
nervous system
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:151962 Fig. 4 J:220523 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 101 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory