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Runx1tm1(cre/Esr1*)Ims - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Runx1tm1(cre/Esr1*)Ims
runt related transcription factor 1; targeted mutation 1, Igor M Samokhvalov 		Driver: Runx1
Type: Targeted (Hypomorph, Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Runx1Cre, Runx1CreER, Runx1MER-Cre-MER, Runx1tm1(cre)Ims
Molecular description: A targeting vector was designed to insert a tamoxifen-inducible cre recombinase flanked by two mutated estrogen receptors and a floxed neo into the Runx1 gene downstream of the proximal (P2) promoter. The neo was subsequently removed via exogenous cre expression. A subsequent reference states that the allele was determined to be hypomorphic, with homozygotes developing to term but dying in the first postnatal day.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Runx1tm1(cre/Esr1*)Ims activity also observed in:
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Images
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J:121435 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory