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Tg(Cyp19a1-cre)5912Gle - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Cyp19a1-cre)5912Gle
transgene insertion 5912, Gustavo Leone 		Driver: Cyp19a1
Type: Transgenic (Recombinase)
Synonym: CYP19-Cre
Molecular description: This transgene uses the cytochrome P450, family 19, subfamily a, polypeptide 1 promoter to drive expression of cre recombinase in the placenta. The transgene also contains an IRES-luciferase, the rabbit beta-globin intron and the SV-40 polyA signal. When crossed to R26R reporter mice, the 5912 founder line exhibited cre activity throughout the spongiotrophoblast and labyrinth trophoblast of E13.5 placentas (only a small percentage of fetuses display X-gal in the internal organs.) The transgene is active by E6.5 in early diploid trophoblast cells having initiated commitment to a differentiated state but is inactive in early, undifferentiated trophoblast stem cells. Strength of cre expression was related to parental inheritance, with maternal inheritance providing the strongest, most consistent placental expression. This line was studied in detail.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Cyp19a1-cre)5912Gle activity also observed in:
embryo-other, extraembryonic component, head, integumental system, reproductive system, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:121714 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 23 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory