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Tg(Rxfp2-cre)5Aia - Mesenchyme
Recombinase Activity Detail
Allele Information
Allele:
Tg(Rxfp2-cre)5Aia
transgene insertion 5, Alexander I Agoulnik 		Driver: Rxfp2
Type: Transgenic (Recombinase)
Synonym: Rxfp2-iCre, Tg(Rxfp2-iCre)AIA
Molecular description: The transgene comprises the 2429 base pairs that reside immediately upstream of the translation initiation codon of the relaxin/insulin-like family peptide receptor 2 gene, a 1.1-kb DNA fragment containing a consensus Kozak sequence, and coding sequences for the nuclear localization signal of the SV40 large T antigen and for improved Cre recombinase (iCre). Examination of X-gal-stained tissues from male mice bearing both this and the Cre-reporter transgene Gt(ROSA)26tm1Sor demonstrate Cre expression in the testis, epididymis and cremaster muscle of the adult and in the developing testis, epididymis and gubernacular ligaments at embryonic day 14 (E14). RT-PCR analysis of male embryonic tissues confirmed this expression, though only weakly in the vas deferens. Expression is 20-fold over endogenous levels.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Rxfp2-cre)5Aia activity also observed in:
reproductive system
Tissue Information
Mesenchyme Other recombinase alleles with activity in Mesenchyme tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory