About   Help   FAQ
Tg(Ddx4-cre)1Dcas - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ddx4-cre)1Dcas
transgene insertion 1, Diego H Castrillon 		Driver: Ddx4
Type: Transgenic (Null/knockout, Recombinase)
Synonym: Mvh-Cre, Vasa-Cre
Molecular description: A 5.6kb fragment of the Ddx4 promoter was ligated to the cre open reading frame with an engineered nuclear localization signal. Eight transgenic lines were created but only two possessed expressing in the gonads as early as E15. When the cre transgene is maternally expressed, all progeny can show ubiquitous recombination even if the cre is not inherited, likely due to perdurance of cre protein in the egg. The transgene integrated into chromosome 18 causing a 1098 Kb deletion and deleting the genes Neto1 and Cbln2. The deletion results in a functional knock-out of both genes in homozygous mice. Founder line 1 has a copy number of greater than 20.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ddx4-cre)1Dcas activity also observed in:
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:260776 Full Image
Fig. Ddx4 adult colon1 J:260776 Full Image
Fig. Ddx4 adult colon2 J:260776 Full Image
Fig. Ddx4 adult colon3 J:260776 Full Image
Fig. Ddx4 adult pancreas1 J:260776 Full Image
Fig. Ddx4 adult pancreas2 J:260776 Full Image
Fig. Ddx4 adult pancreas3 J:260776 Full Image
Fig. Ddx4 adult salv1 J:260776 Full Image
Fig. Ddx4 adult salv2
J:260776 Full Image
Fig. Ddx4 adult salv3 J:260776 Full Image
Fig. Ddx4 adult Sintest1 J:260776 Full Image
Fig. Ddx4 adult Sintest2 J:260776 Full Image
Fig. Ddx4 adult Sintest3 J:260776 Full Image
Fig. Ddx4 adult Stomach1 J:260776 Full Image
Fig. Ddx4 adult Stomach2 J:260776 Full Image
Fig. Ddx4 adult Stomach3 J:260776 Full Image
Fig. Ddx4 adult thyroid1
J:260776 Full image
Fig. Ddx4 adult thyroid2 J:260776 Full image
Fig. Ddx4 adult thyroid3 J:260776 Full Image
Fig. Ddx4 E10.5 hindgut2 J:260776 Full Image
Fig. Ddx4 E10.5 liver J:260776 Full Image
Fig. Ddx4 E10.5 midgut J:260776 Full Image
Fig. Ddx4 E10.5 oesophagus J:260776 Full Image
Fig. Ddx4 E10.5 oral epi J:260776 Full image
Fig. Ddx4 E10.5 stomach
J:260776 Full Image
Fig. Ddx4 E15.5 eosophagus J:260776 Full Image
Fig. Ddx4 E15.5 hindgut J:260776 Full Image
Fig. Ddx4 E15.5 meckles J:260776 Full Image
Fig. Ddx4 E15.5 midgut J:260776 Full Image
Fig. Ddx4 E15.5 mouth layers J:260776 Full Image
Fig. Ddx4 E15.5 oralepithelium J:260776 Full Image
Fig. Ddx4 E15.5 pharynx J:260776 Full Image
Fig. Ddx4 E15.5 salivary
J:260776 Full Image
Fig. Ddx4 E15.5 stomach J:260776 Full Image
Fig. Ddx4 E15.5 thymus J:260776 Full Image
Fig. Ddx4 E15.5 tongue J:260776 Full Image
Fig. Ddx4 E15.5 tooth J:260776 Full Image
Fig. Ddx4 E15.5 tooth upper
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 180 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory