|
|
|
Allele Information
|
|
Allele:
|
Tg(Ddx4-cre)1Dcas
transgene insertion 1, Diego H Castrillon
|
Driver: Ddx4
Type: Transgenic
(Null/knockout, Recombinase)
|
|
|
Synonym:
|
Mvh-Cre, Vasa-Cre
|
|
Molecular description:
|
A 5.6kb fragment of the Ddx4 promoter was ligated to the cre open reading frame with an engineered nuclear localization signal. Eight transgenic lines were created but only two possessed expressing in the gonads as early as E15. When the cre transgene is maternally expressed, all progeny can show ubiquitous recombination even if the cre is not inherited, likely due to perdurance of cre protein in the egg. The transgene integrated into chromosome 18 causing a 1098 Kb deletion and deleting the genes Neto1 and Cbln2. The deletion results in a functional knock-out of both genes in homozygous mice. Founder line 1 has a copy number of greater than 20.
|
|
Find mice (IMSR):
|
Mouse Strains:
2
strains available
Cell Lines:
0 lines available
|
|
Additional Tissues:
|
Tg(Ddx4-cre)1Dcas activity also observed in:
adipose tissue,
alimentary system,
branchial arches,
cardiovascular system,
cavities & their linings,
embryo-other,
endocrine system,
extraembryonic component,
head,
integumental system,
limbs,
liver & biliary system,
mesenchyme,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system,
tail
(less)
|
|
|
Tissue Information
|
|
Hemolymphoid System
|
Other recombinase alleles with activity in Hemolymphoid System tissues:
Abcg2tm1.1(cre/Esr1*)Jvbe,
Agrptm1(cre)Lowl,
Airetm3(cre)Mmat,
Aldh1l1em1(cre/ERT2)Nju,
Alpltm1(cre)Nagy,
Amhr2em1(icre)Fjd,
Aplnrem3(cre/ERT2)Smoc,
Bhlhe41em1(cre)Cya,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cd19tm1(cre)Cgn,
Cd209btm1.1(cre,HBEGF)Bcgen,
Cd34tm1.1(cre/ERT2)Lizg,
Cd40lgtm1.1(icre)Tega,
Clec11aem3(cre/ERT2)Sjm,
Clec9atm2.1(icre)Crs,
Clutm2(EGFP/cre/ERT2)Wtsi,
Col2a1em2(dre)Smoc,
Commd10Tg(Vav1-icre)A2Kio,
Crhtm1(cre)Zjh,
Crybb1em1(icre)Cln,
Cx3cr1tm1.1(cre)Jung,
Cx3cr1tm2.1(cre/ERT2)Jung,
Cx3cr1tm2.1(cre/ERT2)Litt,
Cxcr4tm1.1(cre/ERT2)Stum,
Cxcr5em1(cre/ERT2)Yhar,
Ddx4em1(cre/ERT2)Utr,
Dmp1tm1(cre)Msue,
Dnttem2(icre)Trx,
Dpttm1.1(cre/ERT2)Snjt,
E2f1Tg(Wnt1-cre)2Sor,
Emx1tm1(cre)Krj,
Eporem1(cre)Bcgen,
Eportm1.1(EGFP/icre)Uk,
Epxtm1.1(cre)Jlee,
Fgf16tm1.1(cre)Sms,
Fgf18tm2.2(cre/ERT2)Dor,
Flt4tm2.1(cre/ERT2)Sgo,
Flt4tm2.1(cre/Esr1*)Ichi,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxd1tm1(GFP/cre)Amc,
Foxn1tm3(cre)Nrm,
Foxp3tm4(YFP/icre)Ayr,
Gad2tm2(cre)Zjh,
Gas1em1(icre/ERT2)Nono,
Gfi1tm1(cre)Gan,
Gja10tm2.1(cre)Kwi,
Glp1rtm1.1(cre)Cors,
Gnao1tm2(EGFP/cre/ERT2)Wtsi,
Golm1tm2(EGFP/cre/ERT2)Wtsi,
Grem1tm1.1(cre/ERT2)Snjt,
Gt(ROSA)26Sorem1(CAG-Ncre/vvd*,-vvd*/Ccre)Larc,
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Gt(ROSA)26Sortm5(dre)Dwi,
Gt(ROSA)26Sortm6(dre/PGR*)Dwi,
Gt(ROSA)26Sortm8(CAG-dre/ERT2)Bzsh,
H2az2Tg(Wnt1-cre)11Rth,
Hlfem1(cre/ERT2)Smoc,
Hoxa11em1(cre/ERT2)Dmwe,
Hprt1tm1(CAG-cre)Mnn,
Hprt1tm364a(CAG-icre/ERT2)Ems,
Ifi208Tg(Cspg4-cre)1Akik,
Ighg1tm1(cre)Cgn,
Ihhem1(Tomm20/mKate2,dre)Xya,
Islrtm1.1(HBEGF,cre)Mat,
Islrtm2.1(cre/ERT2)Mat,
Itga8tm1.1(cre/ERT2)Jomm,
Kittm1.1(cre)Jmol,
Kittm1(cre/ERT2)Dsa,
Kittm2.1(cre/Esr1*)Jmol,
Klrg1tm1.1(EGFP/icre)Flv,
Krt17tm1(cre)Murr,
Leprtm2(cre)Rck,
Ltftm1(icre)Tdku,
Ly6atm1.1(cre/ERT2)Geno,
Ly6atm2.1(cre/Esr1*)Jmol,
Ly6gtm2621(cre)Arte,
Lyve1tm1.1(EGFP/cre)Cys,
Lyz2tm1(cre)Ifo,
Mcm2tm1(cre/ERT2)Scpr,
Mcpt8tm1.1(cre)Ics,
Mecomtm4.1(cre/ERT2)Aspe,
Mki67tm1.1(cre/ERT2)Bsed,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Myh6em2(cre)Smoc,
Ndor1Tg(UBC-cre/ERT2)1Ejb,
Neurod6tm1(cre)Kan,
Nkx2-5tm1(cre)Rjs,
Notch1tm3(cre)Rko,
Osr2tm2(cre)Jian,
P2ry12em1(icre/ERT2)Tda,
Pax3tm1(cre)Joe,
Pdgfratm1.1(EGFP/cre/ERT2)Hyma,
Pgrtm2(cre)Lyd,
Piezo1em2(cre/ERT2)Smoc,
Plxnd1tm2(EGFP/cre/ERT2)Wtsi,
Prlrtm1.1(cre)Uboe,
Prtn3tm1.1(cre/ERT2,CD4*)Wkas,
Psmb11tm1.1(icre)Yout,
Pvalbtm1(cre)Arbr,
Rorbtm1.1(cre)Hze,
Rorcem1.1(cre/ERT2)Ayr,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Siglechtm1.1(icre)Ciphe,
Slc17a6tm2(cre)Lowl,
Slc6a3tm1.1(cre)Bkmn,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Sox17tm4.1(icre/ERT2)Heli,
Sptbtm2(EGFP/cre/ERT2)Wtsi,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tas2r131tm2.1(cre)Uboe,
Tbx21tm1.1(cre/ERT2)Ayr,
Tbx21tm2.1(cre)Ayr,
Tekem1(dre)Bzsh,
Tektm1.1(icre/Esr1*)Hrr,
Tg(Acp5-cre)3Rda,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)79Jme,
Tg(ACTB-cre)1Tes,
Tg(Aicda-cre)9Mbu,
Tg(Aicda-cre,-CD2)1Hon,
Tg(Aicda-cre,-CD2)dME1Hon,
Tg(Aire-cre)1Mnt,
Tg(Aire-cre)410-5Mmat,
Tg(Aire-cre/ERT2*)1Mand,
Tg(Amh-cre)8815Reb,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Ccr2-cre)584Hohl,
Tg(CD2-icre)4Kio,
Tg(Cd4-cre)1Cwi,
Tg(Cdh16-cre)91Igr,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(CDX2-cre)101Erf,
Tg(Chst4-cre)1Hkwa,
Tg(Cldn11-cre/ERT2)151Tmak,
Tg(CMA1-cre)6Thhe,
Tg(CMV-cre)1Cgn,
Tg(CMV-cre)1Nagy,
Tg(Col1a2-cre)23Angl,
Tg(Cr2-cre)3Cgn,
Tg(Csf1r-icre)1Jwp,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Ctgf-cre)2Aibs,
Tg(Cxcl12-icre/ERT2)L289Nono,
Tg(Cxcl13-cre,-tdTomato)719Biat,
Tg(Cyp17a1-icre)AJako,
Tg(Cyp39a1-cre)1Aibs,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Epo-cre)44Mym,
Tg(Epx-EYFP/cre)#Voeh,
Tg(Etv2-cre)#Blk,
Tg(Fabp4-cre)1Rev,
Tg(Fcer2a-cre)5Mbu,
Tg(Fgfr3-icre/ERT2)4-2Wdr,
Tg(Flt3-cre)#Ccb,
Tg(Flt3-cre/ERT2)#Ccb,
Tg(Gata1-cre)1Sho,
Tg(Gata1-cre/ERT2)1Mym,
Tg(Gata1-cre/ERT2)2Mym,
Tg(Gata1-cre/ERT2)L245Jeng,
Tg(Gata1-cre/ERT2)L259Jeng,
Tg(Gata1-icre)1Jtp,
Tg(Gata4*G2-cre)#Roja,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)73.12Mvs,
Tg(Gfap-cre)77.6Mvs,
Tg(Grik4-cre)G32-4Stl,
Tg(GZMB-cre)1Jcb,
Tg(H2-Ead-cre)158Jcb,
Tg(HBB-cre)12Kpe,
Tg(HBB-cre)27038Kpe,
Tg(HBB-cre)27053Kpe,
Tg(Hoxb7-cre)13Amc,
Tg(Hspa2-cre)1Eddy,
Tg(Il7-cre)CRche,
Tg(Itga2b-cre)AParl,
Tg(Itga2b-cre)NE1/21Emam,
Tg(ITGAM-cre)2781Gkl,
Tg(Itgax-cre)1-1Reiz,
Tg(Kdr-cre)15962Brei,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre)1Cgn,
Tg(KRT14-cre)8Brn,
Tg(KRT5-cre/ERT)ICmch,
Tg(KRT5-cre/ERT)SCmch,
Tg(Krt8-cre/ERT2,-GFP)1Xin,
Tg(Lck-cre)1Cwi,
Tg(Lck-cre)548Jxm,
Tg(Lck-icre)3779Nik,
Tg(Lepr-cre/ERT2)#Cya,
Tg(Lepr-cre/ERT2)#Rha,
Tg(LPAR4-cre/ERT2,-EGFP)#Hjcho,
Tg(LTF-EGFP/cre/PGR)15Klin,
Tg(Lyve1-cre/ERT2)49Rtem,
Tg(Mafg-Nrf2/cre,-EGFP)737Hozu,
Tg(Mcpt8-icre/ERT2)#Hkar,
Tg(MMTV-cre)1Mam,
Tg(MMTV-cre)4Mam,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-icre/ERT2)1Soff,
Tg(Myh6-cre)2182Mds,
Tg(Ncr1-cre/EGFP)#Cajv,
Tg(Ncr1-cre/ERT2)#Lll,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre/ERT2)1Adra,
Tg(Neurog3-cre)C1Able,
Tg(Nmur1-icre,-EGFP)1Dart,
Tg(Nr5a1-cre)2Klp,
Tg(Nr5a1-cre)2Lowl,
Tg(Nrp2-cre,-EGFP)#Qsch,
Tg(Pcp2-cre)1Amc,
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut,
Tg(Pdgfrb-cre/ERT2)6096Rha,
Tg(Pdpn-cre)HRkl,
Tg(Pdzk1ip1-cre/ERT2)#Reiz,
Tg(Pf4-icre)Q3Rsko,
Tg(Plp1-cre/ERT)3Pop,
Tg(Prdm1-cre)1Masu,
Tg(Prox1-cre/ERT2)1Tmak,
Tg(Prrx1-cre)1Cjt,
Tg(Ptprc-cre)#Mez,
Tg(Relb-cre)53Rie,
Tg(Retnla-cre)#Voeh,
Tg(Rorc-cre)1Litt,
Tg(Runx1/Hspa1a-cre/ERT2)3-17Itoy,
Tg(Runx1/Hspa1a-cre/ERT2)5-2Itoy,
Tg(S100a4-cre)1Egn,
Tg(S100a4-flpo)3Lba,
Tg(Scnn1a-cre)3Aibs,
Tg(Sim1-cre)1Lowl,
Tg(Sox10-cre)1Wdr,
Tg(Stra8-icre)1Reb,
Tg(Tagln-cre)1Her,
Tg(Tas2r143-cre/ERT2)#Soff,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Arnd,
Tg(Tek-icre/ERT2)1Soff,
Tg(tetO-cre)1Jaw,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Vav1-cre)1Cgp,
Tg(VAV1-cre)1Graf,
Tg(Vav1-cre)8Cgp,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Zp3-cre)3Mrt,
Tlr2tm1(cre)Dfil,
Tlx1tm1.1(cre/ERT2)Rygo,
Tnfrsf11atm1(icre)Wask,
Tnfsf11em2(cre)Htaka,
Twist2tm1.1(cre)Dor,
Vwfem1(cre/ERT2)Cya,
Wt1tm1(EGFP/cre)Wtp,
Xcr1tm2.1(icre)Ciphe
(less)
|
|
|
Images
|
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail.
Reset Images
|
|
Recombinase Activity
|
Click heading to re-sort table.
|
|
References
|
|
Analysis Tools