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Tg(dlx5a-cre)1Mekk - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(dlx5a-cre)1Mekk
transgene insertion 1, Marc Ekker 		Driver: dlx5a
Type: Transgenic (Recombinase)
Synonym: Dlx5/6-Cre, Dlx5/6i-Cre, line 8561, Tg(dlx6a-cre)1Mars, Tg(dlx6a-cre)1Mekk
Molecular description: A cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sortm1Sor.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(dlx5a-cre)1Mekk activity also observed in:
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 139 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory