Prox1<tm3(cre/ERT2)Gco> - Head Recombinase Activity Detail MGI Mouse

Prox1^{tm3(cre/ERT2)Gco} - Head
Recombinase Activity Detail

Allele Information | Tissue Information | Recombinase Activity | References

Allele Information

Allele:

Prox1^{tm3(cre/ERT2)Gco}
prospero homeobox 1; targeted mutation 3, Guillermo Oliver

Driver: Prox1
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Prox1^CreER, Prox1-CreER^T2, Prox-1CreER^T2, Prox1^ert2cre, Prox1^{tm3(cre/ERT2)Gco}, Prox1^{tm3(cre/ESR1)Gco}

Molecular description:

A synthetic splice acceptor site, exons 3 and 4, and an IRES-cre/ERT2 cassette were inserted into intron 2 along with a neo and thymidine kinase cassettes. Insertion was confirmed by Southern blot analysis and through crosses with reporter lines. Expression of cre is tamoxifen inducible and recapitulates endogenous promoter activity specifically in the central nervous system, eye, liver, heart, branchial arches and lymphatic endothelial cells.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Prox1^{tm3(cre/ERT2)Gco} activity also observed in:
sensory organs

Tissue Information

Head

Other recombinase alleles with activity in Head tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acan^{tm1(cre/ERT2)Crm}, Acsm4^tm1(cre)Hsak ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

74 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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