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Tg(Itgax-cre)1-1Reiz - Mesenchyme
Recombinase Activity Detail
Allele Information
Allele:
Tg(Itgax-cre)1-1Reiz
transgene insertion 1-1, Boris Reizis 		Driver: Itgax
Type: Transgenic (Recombinase)
Synonym: Cd11c-cre, CD11cCre, CD11cCreT
Molecular description: A transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%).
Find mice (IMSR): Mouse Strains: 4 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Itgax-cre)1-1Reiz activity also observed in:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 675 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory