About   Help   FAQ
Tg(Itgax-cre)1-1Reiz - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Itgax-cre)1-1Reiz
transgene insertion 1-1, Boris Reizis 		Driver: Itgax
Type: Transgenic (Recombinase)
Synonym: Cd11c-cre, CD11cCre, CD11cCreT
Molecular description: A transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%).
Find mice (IMSR): Mouse Strains: 4 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Itgax-cre)1-1Reiz activity also observed in:
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:184579 Full Image
Fig. Itgax Lung P56 J:184579 Full Image
Fig. Itgax P7 Lung
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 675 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory