About   Help   FAQ
Gt(ROSA)26Sortm2(cre/ERT2)Brn - Liver & Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm2(cre/ERT2)Brn
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Anton Berns 		Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: ERT2, Gt(ROSA)26Sortm2(cre/Esr1)Brn, Rosa26CreERT2, ROSA26-CreERT2
Molecular description: The endogenous locus was modified by insertion into the first intron of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT2 fusion gene, which encodes Cre recombinase joined to a mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Western blot analysis confirmed expression of the cre/ERT2 fusion product.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm2(cre/ERT2)Brn activity also observed in:
Tissue Information
Liver & Biliary System Other recombinase alleles with activity in Liver & Biliary System tissues:
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 104 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory