Lgr5<tm1(cre/ERT2)Cle> - Head Recombinase Activity Detail MGI Mouse

Lgr5^{tm1(cre/ERT2)Cle} - Head
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Lgr5^{tm1(cre/ERT2)Cle}
leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers

Driver: Lgr5
Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)

Inducer:

tamoxifen

Synonym:

Lgr5-cre, Lgr5CREER, Lgr5-creERT, Lgr5-CreERT2-IRES-EGFP, Lgr5-EGFP, Lgr5 EGFP-IRES-creERT2, Lgr5-EGFP-IRES-creERT2, Lgr5^{tm1(cre/ESR1)Cle}, Lgr5^UT

Molecular description:

An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Lgr5^{tm1(cre/ERT2)Cle} activity also observed in:
alimentary system, integumental system, renal & urinary system, reproductive system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

559 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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