Lgr5<tm1(cre/ERT2)Cle> - Muscle Recombinase Activity Detail MGI Mouse

Lgr5^{tm1(cre/ERT2)Cle} - Muscle
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Lgr5^{tm1(cre/ERT2)Cle}
leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers

Driver: Lgr5
Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)

Inducer:

tamoxifen

Synonym:

Lgr5-cre, Lgr5CREER, Lgr5-creERT, Lgr5-CreERT2-IRES-EGFP, Lgr5-EGFP, Lgr5 EGFP-IRES-creERT2, Lgr5-EGFP-IRES-creERT2, Lgr5^{tm1(cre/ESR1)Cle}, Lgr5^UT

Molecular description:

An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Lgr5^{tm1(cre/ERT2)Cle} activity also observed in:
alimentary system, integumental system, renal & urinary system, reproductive system

Recombinase Activity

Click heading to re-sort table.

Assays Genotypic Background Result Notes

References

All for this allele:

558 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24