About   Help   FAQ
Lgr5tm1(cre/ERT2)Cle - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Lgr5tm1(cre/ERT2)Cle
leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers 		Driver: Lgr5
Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: Lgr5-cre, Lgr5CREER, Lgr5-creERT, Lgr5-CreERT2-IRES-EGFP, Lgr5-EGFP, Lgr5 EGFP-IRES-creERT2, Lgr5-EGFP-IRES-creERT2, Lgr5tm1(cre/ESR1)Cle, Lgr5UT
Molecular description: An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Lgr5tm1(cre/ERT2)Cle activity also observed in:
alimentary system, integumental system, reproductive system
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:328554 Fig. 1
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 558 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory