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Tg(VAV1-cre)1Graf - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(VAV1-cre)1Graf
transgene insertion 1, Thomas Graf 		Driver: Vav1
Type: Transgenic (Recombinase)
Synonym: vav-Cre
Molecular description: A bicistronic sequence coding for Cre recombinase and YFP linked by an IRES domain was placed downstream of human VAV1 promoter sequence and upstream of VAV1 enhancer sequence. The entire construct was flanked by two 250 bp core elements from chicken beta globulin insulator. Transgenic mice failed to express YFP but crossing with a Gt(ROSA)26Sortm1(EYFP)Cos reporter strained revealed that 70% of mice had cre expression restricted to hematopoietic cells, including hematopoietic stem cells. The remaining 30% had cre expression in a wider range of cells, possibly due to transient expression of the transgene in early blastomeres.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(VAV1-cre)1Graf activity also observed in:
hemolymphoid system, liver & biliary system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:127936 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 119 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory