Tg(Nkx2-1-cre)2Sand - Hemolymphoid System Recombinase Activity Detail MGI Mouse

Tg(Nkx2-1-cre)2Sand - Hemolymphoid System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Nkx2-1-cre)2Sand
transgene insertion 2, Stewart Anderson

Driver: Nkx2-1
Type: Transgenic (Recombinase)

Synonym:

Nkx2-1BAC^Cre, Nkx2.1-cre, Nkx2.1^Cre, NKX2.1Cre, Tg(Nkx2-1-cre)1Qixu, Tg(Nkx2-1-cre)2Qixu, Ttf-1^Cre

Molecular description:

A mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5.

Find mice (IMSR):

Mouse Strains: 2 strains available Cell Lines: 0 lines available

Additional Tissues:

Tg(Nkx2-1-cre)2Sand activity also observed in:
alimentary system, endocrine system, head, mesenchyme, nervous system, respiratory system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

206 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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