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Tg(Nkx2-1-cre)2Sand - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nkx2-1-cre)2Sand
transgene insertion 2, Stewart Anderson 		Driver: Nkx2-1
Type: Transgenic (Recombinase)
Synonym: Nkx2-1BACCre, Nkx2.1-cre, Nkx2.1Cre, NKX2.1Cre, Tg(Nkx2-1-cre)1Qixu, Tg(Nkx2-1-cre)2Qixu, Ttf-1Cre
Molecular description: A mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nkx2-1-cre)2Sand activity also observed in:
alimentary system, endocrine system, head, mesenchyme, nervous system
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Images
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J:184579 Full Image
Fig. Nkx2-1 E15.5 Embryo 1 J:184579 Full Image
Fig. Nkx2-1 E15.5 Embryo 2 J:184579 Full Image
Fig. Nkx2-1 E15.5 Embryo 3 J:184579 Full Image
Fig. Nkx2-1 Lung P56 J:184579 Full Image
Fig. Nkx2-1 P7 Lung
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 206 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory