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Nefltm1(cre/ERT)Nat - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Nefltm1(cre/ERT)Nat
neurofilament, light polypeptide; targeted mutation 1, Jeremy Nathans 		Driver: Nefl
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Nefltm1(cre/Esr1)Nat, NFL-IRES-creER, NFL-IRES-creER(T)
Molecular description: An IRES-creER cassette, a tetracycline resistance gene, and a Frt-flanked neomycin selection marker were all knocked in to the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in ganglion cells and horizontal cells of the retina, and in a sparse number of neurons in the brain.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Nefltm1(cre/ERT)Nat activity also observed in:
head, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:144315 Fig. 3 J:144315 Fig. 4 J:144315 Fig. 8
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory