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Gt(ROSA)26Sortm1.1(CAG-cre)Jphe - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Jean-Paul Herman 		Driver: CAG
Type: Targeted (Inducible, Recombinase)
Inducer: rapamycin
Synonym: DiCre, Gt(ROSA)26Sortm1.1(cre)Jphe, Rosa26-DiCre
Molecular description: The expression of a dimerizable cre was achieved by insertion of the cre60.F2 N-terminal cre moiety which is fused to FRB (ligand binding domain of FRAP/MTOR,an FKBP12-rapamycin associated protein) under the control of the endogenous promoter and a Caggs-cre59.F2 cassette, containing the C-teminal moiety of cre fused to FKBP12 (FK506-binding protein) under control of the CAG promoter, into the ROSA locus. A hygro cassette was also inserted into the locus for selection purposes. The split cre is inactive until dimerization is induced by administration of rapamycin. The hygro cassette was removed by crossing F1 Gt(ROSA)26Sortm1(cre)Jphe mice with FLPe mice.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1.1(CAG-cre)Jphe activity also observed in:
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Images
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J:130959 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory