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Foxp3tm4(YFP/icre)Ayr - Mouse-other
Recombinase Activity Detail
Allele Information
Allele:
Foxp3tm4(YFP/icre)Ayr
forkhead box P3; targeted mutation 4, Alexander Y Rudensky 		Driver: Foxp3
Type: Targeted (Recombinase)
Synonym: Foxp3Cre, Foxp3tm4(YFP/cre)Ayr, Foxp3YFP-Cre
Molecular description: A YFP/icre fusion construct with an upstream IRES element and a downstream frt-flanked neomycin resistance cassette was placed into the downstream untranslated region of the gene. Chimeric mice were crossed with FLPe expressing mice to remove the neomycin selection cassette. YFP-cre expression based on YFP flouresecene was only detected in regulatory T cells. Crossing these mice with mice that contain a cre-mediated reporter gene also demonstrated low level cre expression in about 2-10% of hematopoietic lineage cells including immature and mature B cells, T cells, myeloid cells and bone marrow precursor cells.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Foxp3tm4(YFP/icre)Ayr activity also observed in:
hemolymphoid system
Tissue Information
Mouse-other Other recombinase alleles with activity in Mouse-other tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 371 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory