Vamp2<tm1(cre/ERT)Nat> - Head Recombinase Activity Detail MGI Mouse

Vamp2^{tm1(cre/ERT)Nat} - Head
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Vamp2^{tm1(cre/ERT)Nat}
vesicle-associated membrane protein 2; targeted mutation 1, Jeremy Nathans

Driver: Vamp2
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

VAMP2-IRES-creER, Vamp2^{tm1(cre/Esr1)Nat}

Molecular description:

An IRES-creER cassette, a tetracycline resistance gene and a Frt-flanked neomycin selection marker were all knocked in to the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in a wide variety of neural and glial cells of the brain. This is line B4.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Vamp2^{tm1(cre/ERT)Nat} activity also observed in:
nervous system

Tissue Information

Head

Other recombinase alleles with activity in Head tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acan^{tm1(cre/ERT2)Crm}, Acsm4^tm1(cre)Hsak ...(more)

Images

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J:144315 Fig. 2

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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