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Tg(Tg-cre)1Soff - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tg-cre)1Soff
transgene insertion 1, Stefan Offermanns 		Driver: Tg
Type: Transgenic (Recombinase)
Synonym: Tg-cre
Molecular description: A transgenic construct with the coding sequence of the iCre recombinase followed by the bovine GH polyadenylation signal and a frt-flanked ampicillin cassette was fused to sequences from the proximal promoter and first intron of the mouse thyroglobulin (Tg) gene. The whole construct was introduced into the PAC encoding the Tg gene and by homologous recombination, the ATG of the iCre replaced the ATG of the thryoglobulin gene. The ampicillin cassette was removed by Flp-mediated recombination. Cre activity is observed in nearly all thyrocytes, but not in other cells of the thryoid gland after E10.5.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tg-cre)1Soff activity also observed in:
alimentary system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:127484 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory