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Tg(HBB-cre)12Kpe - Liver & Biliary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(HBB-cre)12Kpe
transgene insertion 12, Kenneth Peterson 		Driver: HBB
Type: Transgenic (Recombinase)
Synonym: microLCR-betapr-Cre
Molecular description: A transgenic construct containing the sequence encoding Cre recombinase under the control of the human beta hemoglobin (HBB) promoter, intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR) was introduced into C57BL/6 donor eggs. Founder line 12 was established. Cre recombinase expression is detected in blood, brain, gonads, spleen and liver by RT-PCR analysis and in blood by RNAse protection assay. Recombination occurs at 50-100% efficiency in erythroid/megakarycytic cell lineages beginning at onset of hematopoiesis at approximately embryonic day 7.5.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(HBB-cre)12Kpe activity also observed in:
embryo-other, extraembryonic component, hemolymphoid system, skeletal system
Tissue Information
Liver & Biliary System Other recombinase alleles with activity in Liver & Biliary System tissues:
Images
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J:89725 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory