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Tg(Kap-icre)29066/2Sig - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Kap-icre)29066/2Sig
transgene insertion 29066/2, Curt Sigmund 		Driver: Kap
Type: Transgenic (Inducible, Recombinase)
Inducer: androgen
Synonym: KAP2-iCre, Tg(Kap-cre)29066/2Sig
Molecular description: The Kap promoter and the distal regulatory sequences of the human angiotensinogen gene (AGT), which together confer androgen responsiveness, is used to drive expression of androgen-inducible improved Cre (iCre) in the kidney. The icre cDNA was cloned downstream of the Kap promoter (nucleotides -1542 through -1 relative to the transcription initiation site) into the NotI site of the pKAP2 vector. This is followed by the last 42 bp of human AGT exon 2 through exon 5, which lost their coding potential owing to the lack of the first 817 bp of exon 2 that included the ATG start site. Twenty-six founders were created of which only line 29066/2 expressed cre in male kidneys with some expression in the brain, liver, and heart.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Kap-icre)29066/2Sig activity also observed in:
liver & biliary system, nervous system, renal & urinary system, reproductive system
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:206504 Full Image
Fig. Kap Midbrain P56 J:206504 Full Image
Fig. Kap Pons/Medulla P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory