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Tg(GFAP-cre/Esr1*,-lacZ)BSbk - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(GFAP-cre/Esr1*,-lacZ)BSbk
transgene insertion B, Suzanne J Baker 		Driver: GFAP
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: GFAP-CreERTM, GFAP-CreERTMB, Tg(GFAP-cre/Esr1)BSbk
Molecular description: This transgene consists of a 2.2 kb fragment of the human GFAP promoter, a cDNA encoding a fusion of cre and the ligand binding domain of the human estrogen receptor modified to bind 4-hydroxytamoxifen, but not endogenous estrogen, an IRES, a cDNA encoding beta-galactosidase, and SV40 intronic sequence and polyadenylation signal. Transgene expression, assessed by beta-gal activity, is seen in Bergmann glia, neuronal precursors in the dentate gyrus, and cells in the subventricular zone surrounding the lateral ventricle. When crossed to reporter mice occasional tamoxifen-independent Cre mediated recombination is seen primarily in Bergmann glial cells.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(GFAP-cre/Esr1*,-lacZ)BSbk activity also observed in:
alimentary system, head, renal & urinary system, reproductive system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory