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Mcm2tm1(cre/ERT2)Scpr - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Mcm2tm1(cre/ERT2)Scpr
minichromosome maintenance complex component 2; targeted mutation 1, Steven C Pruitt 		Driver: Mcm2
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Mcm2IRES-CreERT2, Mcm2tm1(cre)Scpr
Molecular description: An IRES element, a cre/ESRI fusion gene. and a PGK-neo selection cassette were inserted into exon 16 3' to the stop codon. A cryptic polyA site 3' of the stop codon was deleted in order to permit cre expression. Cre expression was confirmed by EGFP expression after tamoxifen treatment of mice also carrying the Tg(CAG-Bgeo/GFP)21Lbe transgene. MCM2 expression was reduced to 62% of normal in heterozygotes and 35% in homozygotes.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Mcm2tm1(cre/ERT2)Scpr activity also observed in:
alimentary system, cardiovascular system, head, hemolymphoid system, integumental system, skeletal system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory