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Tg(KRT5-cre/ERT)SCmch - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(KRT5-cre/ERT)SCmch
transgene insertion S, Chun-Ming Chen 		Driver: KRT5
Type: Transgenic (Recombinase)
Synonym: spontaneous BK5-CreERT transgene, Tg(BK5-CreERT)S
Molecular description: This transgene comprises 5.2 kb of 5' flanking and promoter DNA from the bovine keratin 5 gene and a rabbit beta-globin intron followed by the Cre recombinase coding sequence joined in-frame to a mutated estrogen receptor ligand binding domain (ERT), then by an SV40 poly(A) signal and two reversed copies of the ~1.2 kb HS4 5' insulator sequence from the chicken beta-globin gene. Double transgenic mice for cre and the R26-LacZ reporter demonstrate constitive expression (in absence of 4-hydroxy tamoxifen treatment) from about E14.5 in most keratin 5 expressing tissues; the thymic epithelium and the Mullerian vagina show significant expression only after postnatal day 7. Additionally, only this line (in contrast with Tg(KRT5-Cre/ERT)ICmch) exhibits Cre recombinase activity in KRT5-expressing epithelial cells of the mammary gland.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(KRT5-cre/ERT)SCmch activity also observed in:
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:143780 Fig. 3 J:143780 Fig. 5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory