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Tg(REN-cre)1Haca - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Tg(REN-cre)1Haca
transgene insertion 1, Hayo Castrop 		Driver: REN
Type: Transgenic (Recombinase)
Synonym: hRen-cre, Ren-Cre
Molecular description: 12.2 kb of human renin promoter sequence was used to drive expression of cre recombinase. An upstream chicken matrix attachment region element was included to insulate the renin promoter from integration site effects. Five independent lines with stable integration of the transgene were established. Differences in the expression of the transgene between the different lines were marginal. Cre recombinase expression was detected in the renal cortex of adult mice with expression being localized in afferent arterioles and, to a lesser degree, in interlobular arteries. Expression could be modulated by salt intake and water restriction. Crossing this allele with a cre-reporter allele suggests other sites of transgene induction during embryonic development including the branching ureteric bud system of the kidney and in the adrenal cortex.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(REN-cre)1Haca activity also observed in:
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory