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Tg(GH1-cre)1Sac - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(GH1-cre)1Sac
transgene insertion 1, Sally A Camper 		Driver: GH1
Type: Transgenic (Recombinase)
Synonym: Tg(Gh-cre)SAC1
Molecular description: The human growth hormone locus control region (-16.2 to -14.6 kb relative to the GH1 promoter) was fused to 1.77 kb of rat Gh1 promoter to drive expression of a cre recombinase cassette in the pituitary gland. About 30-50 copies of the transgene construct inserted into the genome after injection into zygotes. When crossed with cre-reporter strains, cre expression was observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression was also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(GH1-cre)1Sac activity also observed in:
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:144723 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory