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Tg(GFAP-Ncre)VFki - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(GFAP-Ncre)VFki
transgene insertion V, Frank Kirchhoff 		Driver: GFAP
Type: Transgenic (Recombinase)
Synonym: GCNV, GFAP-NCre, Tg(GFAP-icre*)VFki
Molecular description: The coding sequence for improved cre recombinase was split into two complementary halves. For this transgene construct, the n-terminal half of the cre gene encoding for amino acids 19-59 was fused on its 5' end to an element encoding the coiled-coil leucine zipper domain of the yeast transcription factor GCN4. A Flag tag was also included on the 5' end of the fused construct. This construct was placed under control of the human GFAP promoter to drive expression in astrocytes. When this transgene is co-expressed with a transgene that expresses the c-terminal half of icre fused to a leucine zipper domain, the leucine zippers force dimerization resulting in a functional cre recombinase. This line is one of four lines created (Q, T, V, W).
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(GFAP-Ncre)VFki activity also observed in:
head, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:144851 Fig. 2 J:144851 Fig. S6 (GFP-NCre x PLP-CCre)
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory