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Tg(Tek-icre/ERT2)1Soff - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Tek-icre/ERT2)1Soff
transgene insertion 1, Stefan Offermanns 		Driver: Tek
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: tie2-CreERT2
Molecular description: A tamoxifen-inducible icre recombinase gene and FRT-flanked beta-lactamase gene were inserted into the ATG start site of the murine Tek gene located on a BAC. After Flpe-mediated excision of the beta-lactamase gene, the targeted BAC was injected into FVB/N oocytes. Cre expression was detected in endothelial cells of numerous organs after treatment with tamoxifen.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Tek-icre/ERT2)1Soff activity also observed in:
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:146132 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory