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Tg(Ctgf-cre)2Aibs - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ctgf-cre)2Aibs
transgene insertion 2, Ed Lein 		Driver: Ccn2
Type: Transgenic (Recombinase)
Synonym: Ctgf-Tg2-Cre
Molecular description: The 189 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-257E12, containing the entire Ctgf locus (and other genes), was modified by targeting a Cre recombinase coding sequence (the CreERT2 sequence modified back to encode the normal Cre recombinase gene), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Ctgf locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre expression is directed to cortex and hippocampus by the Ctgf promoter/enhancer regions within the BAC transgene.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ctgf-cre)2Aibs activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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Fig. CDX2 E10.5 Neural tube J:216865 Full Image
Fig. Ctgf adult brain J:216865 Full Image
Fig. Ctgf adult cerv sc J:216865 Full Image
Fig. Ctgf adult eye J:216865 Full Image
Fig. Ctgf adult lumbar sc J:216865 Full Image
Fig. Ctgf adult thor sc J:216865 Full Image
Fig. Ctgf E10.5 DRG J:216865 Full Image
Fig. Ctgf E10.5 fore/mid brain
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Fig. Ctgf E15.5 brain J:216865 Full Image
Fig. Ctgf E15.5 DRG J:216865 Full Image
Fig. Ctgf E15.5 spinal chord
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory