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Tg(Wfs1-cre/ERT2)3Aibs - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Wfs1-cre/ERT2)3Aibs
transgene insertion 3, Ed Lein 		Driver: Wfs1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Wfs1-Tg3-CreERT2
Molecular description: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405O19, containing the entire Wsf1 locus (and other genes), was modified by targeting a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand-binding domain), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Wsf1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre activity is directed to the cortex, hippocampus, striatum, thalamus, and cerebellum only following tamoxifen administration.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Wfs1-cre/ERT2)3Aibs activity also observed in:
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:184579 Full Image
Fig. Wsf1 Adrenal P56 J:184579 Full Image
Fig. Wsf1 Pancreas P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory