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Tg(Gfap-cre)77.6Mvs - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gfap-cre)77.6Mvs
transgene insertion 77.6, Michael V Sofroniew 		Driver: Gfap
Type: Transgenic (Recombinase)
Synonym: mGFAP-Cre
Molecular description: The bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gfap-cre)77.6Mvs activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:146630 Fig. 1 J:193672 Full Image
Fig. Gfap Brain P56 J:193672 Full Image
Fig. Gfap Optic Nerve P56 J:193672 Full Image
Fig. Gfap Pituitary P56 J:193672 Full Image
Fig. Gfap Sp Cord (Cerv) P56 J:193672 Full Image
Fig. Gfap Sp Cord (Lumb) P56 J:193672 Full Image
Fig. Gfap Sp Cord (Thor) P56 J:241606 Fig. 1B
J:241606 Fig. 5A
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 118 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory