The transgenic construct contains the 4.1 kb human pro-surfactant protein C promoter (from an RPCl-11 human BAC clone) driving the Cre recombinase sequence. This construct was injected into the pronuclei of C57BL/6 blastocysts. Five founders were generated, and from crosses to transgenic reporter mice, lines 11 and 14 exhibited reporter expression in the lungs. Both lines contain a single transgene copy and were propagated for further study.
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