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Tg(Rr141-cre)1Ksec - Skeletal System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Rr141-cre)1Ksec
transgene insertion 1, Katheryn S E Cheah 		Driver: Hoxb2
Type: Transgenic (Recombinase)
Synonym: B2-r4-Cre, Tg(Hoxb2-cre)1Ksec
Molecular description: The 3.4 kb transgene construct contained a 1.4 kb genomic fragment containing murine Hoxb2 rhombomere 4 (r4) enhancer Rr141 inserted upstream of the beta-globin promoter to drive expression of cre cDNA with a nuclear localization signal (NLS). Five founder lines were generated. Line 5 showed mosaic expression when crossed to R26R reporter animals, while the remaining 4 recapitulated the Hoxb2-r4 expression pattern as reported previously. Lines 3 and 4 showed higher background staining while line 1 showed stronger cre activity than line 2. Line 1 was used for subsequent analyses.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Rr141-cre)1Ksec activity also observed in:
branchial arches, cardiovascular system, embryo-other, head, nervous system, sensory organs
Tissue Information
Skeletal System Other recombinase alleles with activity in Skeletal System tissues:
Images
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J:149900 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory