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Tg(Scnn1a-cre)3Aibs - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Scnn1a-cre)3Aibs
transgene insertion 3, Ed Lein 		Driver: Scnn1a
Type: Transgenic (Recombinase)
Synonym: Scnn1a-Tg3-Cre
Molecular description: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405B24, containing the entire Scnn1a locus (and other genes), was modified by targeting a Cre recombinase coding sequence (the CreERT2 sequence modified back to encode the normal Cre recombinase gene), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Scnn1a locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. The resulting modified BAC was microinjected into embryos from B6C3 mice ((C57BL/6 x C3H)F1 x C57BL/6). Transgenic males from founder line Scnn1a-Tg3-Cre was bred to C57BL/6J females to generate the colony.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Scnn1a-cre)3Aibs activity also observed in:
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Images
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J:193672 Full Image
Fig. Scnn1a P56 Lung J:193672 Full Image
Fig. Scnn1a P56 Trachea
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 86 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory