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Tg(Ins1-cre/ERT)1Lphi - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ins1-cre/ERT)1Lphi
transgene insertion 1, Louis Philipson 		Driver: Ins1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: MIP-CreER, MIP-Cre/ERT, MIP-CreERT1Lphi
Molecular description: An 8.3 kb fragment of the mouse insulin promoter (Ins1; from nucleotide -8280 to +12 relative to the transcriptional start site) drives cDNA encoding cre recombinase fused to the mutated mouse estrogen receptor ligand-binding domain. A 2.1 kb fragment of the hGH gene was added to function as a transcriptional stop signal. The 12.5 kb construct was purified and microinjected into fertilized pronuclei of CD1 mice. Line 1 was established.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ins1-cre/ERT)1Lphi activity also observed in:
endocrine system
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 100 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory