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Gad2tm2(cre)Zjh - Cavities & Their Linings
Recombinase Activity Detail
Allele Information
Allele:
Gad2tm2(cre)Zjh
glutamic acid decarboxylase 2; targeted mutation 2, Z Josh Huang 		Driver: Gad2
Type: Targeted (Recombinase)
Synonym: Gad2Cre, Gad2-iCre, Gad2-ires-Cre, GAD65-Cre, GAD65-iCre, GAD65-ires-Cre
Molecular description: A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, an SV40 polyA signal, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the Gad2 (glutamic acid decarboxylase 2) gene. This construct was electroporated into C57BL6/S129 hybrid embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient tetraploid blastocysts. Chimeric mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background (N10)) to remove the selection cassette. The FLPe transgene was subsequently bred out of the background.
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 3 strains available       Cell Lines: 0 lines available
Additional Tissues: Gad2tm2(cre)Zjh activity also observed in:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 362 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory