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Sox17tm2.1(icre)Heli - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Sox17tm2.1(icre)Heli
SRY (sex determining region Y)-box 17; targeted mutation 2.1, Heiko Lickert 		Driver: Sox17
Type: Targeted (Recombinase)
Synonym: Sox17- 2Aicre, Sox17-2A-iCre, Sox172A-iCre, Sox172A-iCredeltaneo, Sox17tm2.1(icre)Lic
Molecular description: The Sox17 translational stop codon in exon 5 was replaced by a T2A (Thosea asigna virus, TaV) self-cleaving peptide followed by the improved Cre (iCre) for the efficient and equimolar translation of Sox17 and icre. Sox17 and icre are postranslationally cleaved by a 2A-mediated ribosome-skipping mechanism. The FRT-flanked neo selection cassette was subsequently deleted in the germline by FLP-mediated recombination.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Sox17tm2.1(icre)Heli activity also observed in:
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:155991 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory