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Tg(Gjb6-cre/ERT2)53-33Fwp - Alimentary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gjb6-cre/ERT2)53-33Fwp
transgene insertion 53-33, Frank W Pfrieger 		Driver: Gjb6
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Cx30-CreERT2, Tg(Cx30-CreERT2)53-33
Molecular description: The creERT2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Gjb6 gene located in BAC RP24-368M7. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. Line 53-33 displayed high quantities of CreERT2 transcripts in several brain regions including cortex, cerebellum, hippocampus, mesencephalon, and medulla oblongata. CreERT2 and Cx30 mRNA were also present in the skin.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gjb6-cre/ERT2)53-33Fwp activity also observed in:
cardiovascular system, head, muscle, nervous system, respiratory system
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory