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Tg(Slc1a3-cre/ERT2)45-72Fwp - Respiratory System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc1a3-cre/ERT2)45-72Fwp
transgene insertion 45-72, Frank W Pfrieger 		Driver: Slc1a3
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Glast-CreERT2, GLAST::CreERT2, Tg(Glast-CreERT2)45-72
Molecular description: The creERT2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Slc1a3 (Glast) gene located in BAC RP23-63O21. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. Line 45-72 showed the highest level of Cre expression, which corresponded to the strong presence of Slc1a3 transcripts. Other regions of the CNS also contained CreERT2 transcripts, but at lower levels. CreERT2 mRNA was also detected in the skin and testis in agreement with elevated Slc1a3 transcript levels in these tissues.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc1a3-cre/ERT2)45-72Fwp activity also observed in:
head, muscle, nervous system, sensory organs
Tissue Information
Respiratory System Other recombinase alleles with activity in Respiratory System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory