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Tg(Ppp1r2-cre)4127Nkza - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ppp1r2-cre)4127Nkza
transgene insertion 4127, Kazu Nakazawa 		Driver: Ppp1r2
Type: Transgenic (Recombinase)
Synonym: Cre #4127, Ppp1r2-cre
Molecular description: BAC homologous recombination was used to insert cre cDNA (fused with a nuclear localization signal (NLS) sequence) immediately upstream of the initiation codon of the Ppp1r2 gene in BAC RPCI-24-322B4. The cre cDNA was followed by the bovin growth hormone-derived polyadenylation signal. In one clone, a 12-kb deletion introduced around the initial methionine codon of the apolipoprotein D (Apod) coding sequence, located 50 kb upstream of Ppp1r2, was identified. This clone was used to prevent overexpression of Apod in the brain of transgenic mice.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Ppp1r2-cre)4127Nkza activity also observed in:
nervous system
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory