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Lyve1tm1.1(EGFP/cre)Cys - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Lyve1tm1.1(EGFP/cre)Cys
lymphatic vessel endothelial hyaluronan receptor 1; targeted mutation 1, Jason G Cyster 		Driver: Lyve1
Type: Targeted (Recombinase)
Synonym: Lyve-1 Cre+, Lyve-1 EGFP-hCre
Molecular description: An EGFP fused to a humanized cre (hCre) sequence and preceded by an internal ribosomal entry site (IRES) was inserted into the 3' UTR of the Lyve1 locus by homologous recombination in E14 ES cells. This construct was followed by an FRT-flanked neo selection cassette. Three successfully targeted clones were injected into C57BL/6 blastocysts and chimeras derived from clone 9 were bred to get germline transmission. The neo cassette was deleted in the germline with Flp recombinase. Selective GFP expression in nuclei of Lyve1 +ve cells is detected by antibody staining.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Lyve1tm1.1(EGFP/cre)Cys activity also observed in:
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:206504 Full Image
Fig. Lyve1 Bladder P56 J:206504 Full Image
Fig. Lyve1 Kidney P56 J:206504 Full Image
Fig. Lyve1 Renal System E15.5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 65 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory